धीधृतिस्मृतिविभ्रंशः सम्प्राप्तिः कालकर्मणाम् ।
असात्म्यार्थागमश्चेति ज्ञातव्या दुःखहेतवः ॥
dhī-dhṛti-smṛti-vibhraṁśaḥ samprāptiḥ kāla-karmaṇām |
asātmyārthāgamaś ceti jñātavyā duḥkha-hetavaḥ ||
(Caraka-saṁhita: 4.1.98)
“Divergence of the intellect, will, or memory [i.e., prajñāparādhas], the onset of a time period [e.g., a season], karma [i.e., the results of one‘s past actions], and contact with unwholesome objects of the senses are to be known as causes of suffering.”